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Merck

IMPDH2

IMP (inosine 5'-monophosphate) dehydrogenase 2

Synonyms:
IMPD2, IMPDH-II
Species:
Human IMPDH2 (3615), Mouse Impdh2 (23918), Rat Impdh2 (301005), dog IMPDH2 (476630), Zebrafish impdh2 (317745), domestic guinea pig Impdh2 (100730768), naked mole-rat Impdh2 (101701391), domestic cat IMPDH2 (101080693), cow IMPDH2 (511969), sheep IMPDH2 (101107823) ...More
UniProtKB ID:
P12268, Q6LEF3
Gene ID:
  • Human(3615) Summary: This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]
  • Mouse(23918) inosine 5'-phosphate dehydrogenase 2
  • Rat(301005) IMP (inosine 5'-monophosphate) dehydrogenase 2
  • dog(476630) IMP (inosine 5'-monophosphate) dehydrogenase 2
  • Zebrafish(317745) IMP (inosine monophosphate) dehydrogenase 2
  • domestic guinea pig(100730768) IMP (inosine 5'-monophosphate) dehydrogenase 2
  • naked mole-rat(101701391) IMP (inosine 5'-monophosphate) dehydrogenase 2
  • domestic cat(101080693) IMP (inosine 5'-monophosphate) dehydrogenase 2
  • cow(511969) IMP (inosine 5'-monophosphate) dehydrogenase 2
  • sheep(101107823) IMP (inosine 5'-monophosphate) dehydrogenase 2
  • Domestic Rabbit(100355621) IMP (inosine 5'-monophosphate) dehydrogenase 2
  • chicken(416058) IMP (inosine 5'-monophosphate) dehydrogenase 2
  • Horse(100063255) IMP (inosine 5'-monophosphate) dehydrogenase 2

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Small Molecule - Inhibitor

Product Number
Description
Species
R9644
Ribavirin, antiviral,
Species
human
BP878
Tioguanine, British Pharmacopoeia (BP) Reference Standard,
Species
human
Y0000519
Mycophenolate mofetil for peak identification, European Pharmacopoeia (EP) Reference Standard,
Species
human
1660000
Thioguanine, United States Pharmacopeia (USP) Reference Standard,
Species
human
Y0000489
Mycophenolate mofetil, European Pharmacopoeia (EP) Reference Standard,
Species
human