IMPA1
inositol(myo)-1(or 4)-monophosphatase 1
Synonyms:
IMP, IMPA
Species:
Human IMPA1 (3612), Mouse Impa1 (55980), Rat Impa1 (83523), domestic guinea pig Impa1 (100723610), naked mole-rat Impa1 (101704416), domestic cat IMPA1 (101088214), cow IMPA1 (281865), sheep IMPA1 (101119912), chicken IMPA1 (420199), dog IMPA1 (477925)
UniProtKB ID:
Gene ID:
- Human(3612) Summary: This gene encodes an enyzme that dephosphorylates myo-inositol monophosphate to generate free myo-inositol, a precursor of phosphatidylinositol, and is therefore an important modulator of intracellular signal transduction via the production of the second messengers myoinositol 1,4,5-trisphosphate and diacylglycerol. This enzyme can also use myo-inositol-1,3-diphosphate, myo-inositol-1,4-diphosphate, scyllo-inositol-phosphate, glucose-1-phosphate, glucose-6-phosphate, fructose-1-phosphate, beta-glycerophosphate, and 2'-AMP as substrates. This enzyme shows magnesium-dependent phosphatase activity and is inhibited by therapeutic concentrations of lithium. Inhibition of inositol monophosphate hydroylosis and subsequent depletion of inositol for phosphatidylinositol synthesis may explain the anti-manic and anti-depressive effects of lithium administered to treat bipolar disorder. Alternative splicing results in multiple transcript variants encoding distinct isoforms. A pseudogene of this gene is also present on chromosome 8q21.13. [provided by RefSeq, Nov 2009]
- Mouse(55980) inositol (myo)-1(or 4)-monophosphatase 1
- Rat(83523) Inositol (myo)-1(or 4)-monophosphatase 1
- domestic guinea pig(100723610) inositol(myo)-1(or 4)-monophosphatase 1
- naked mole-rat(101704416) inositol(myo)-1(or 4)-monophosphatase 1
- domestic cat(101088214) inositol(myo)-1(or 4)-monophosphatase 1
- cow(281865) inositol(myo)-1(or 4)-monophosphatase 1
- sheep(101119912) inositol(myo)-1(or 4)-monophosphatase 1
- chicken(420199) inositol(myo)-1(or 4)-monophosphatase 1
- dog(477925) inositol(myo)-1(or 4)-monophosphatase 1
- Zebrafish(437018) inositol(myo)-1(or 4)-monophosphatase 1
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