IDO1
indoleamine 2,3-dioxygenase 1
Synonyms:
IDO, IDO-1, INDO
Species:
Human IDO1 (3620), Mouse Ido1 (15930), Rat Ido1 (66029), Zebrafish ido1 (571967), dog IDO1 (475574), domestic guinea pig Ido1 (100728309), naked mole-rat Ido1 (101723745), domestic cat IDO1 (101096977), cow IDO1 (506281), sheep IDO1 (100196903)
UniProtKB ID:
Gene ID:
- Human(3620) Summary: This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
- Mouse(15930) indoleamine 2,3-dioxygenase 1
- Rat(66029) indoleamine 2,3-dioxygenase 1
- Zebrafish(571967) indoleamine 2,3-dioxygenase 1
- dog(475574) indoleamine 2,3-dioxygenase 1
- domestic guinea pig(100728309) indoleamine 2,3-dioxygenase 1
- naked mole-rat(101723745) indoleamine 2,3-dioxygenase 1
- domestic cat(101096977) indoleamine 2,3-dioxygenase 1
- cow(506281) indoleamine 2,3-dioxygenase 1
- sheep(100196903) indoleamine 2,3-dioxygenase 1
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-IDO Antibody, Chemicon®, from rabbit,
Species Reactivity
mouse
Application
ELISA
western blot
western blot
Anti-Indoleamine 2,3-dioxygenase Antibody, clone 10.1, clone 10.1, Chemicon®, from mouse,
Species Reactivity
human, mouse, rat
Application
immunohistochemistry
western blot
western blot
Anti-IDO Antibody, clone 1F8.2, clone 1F8.2, from mouse,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-IDO (Indoleamine 2,3-Dioxygenase) Antibody, clone 10.1, clone 10.1, Upstate®, from mouse,
Species Reactivity
human, mouse
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot