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Merck

HTRA4

HtrA serine peptidase 4

Synonyms:
Species:
Human HTRA4 (203100), Mouse Htra4 (330723), Rat Htra4 (306564), cow HTRA4 (514946), dog HTRA4 (475580)
UniProtKB ID:
P83105, Q542Z4, Q6PF13
Gene ID:
  • Human(203100) Summary: This gene encodes a member of the HtrA family of proteases. The encoded protein contains a putative signal peptide, an insulin growth factor binding domain, a Kazal protease inhibitor domain, a conserved trypsin domain and a PDZ domain. Based on studies on other related family members, this enzyme may function as a secreted oligomeric chaperone protease to degrade misfolded secretory proteins. Other human HtrA proteins have been implicated in arthritis, tumor suppression, unfolded stress response, apoptosis, and aging. [provided by RefSeq, Oct 2008]
  • Mouse(330723) HtrA serine peptidase 4
  • Rat(306564) HtrA serine peptidase 4
  • cow(514946) HtrA serine peptidase 4
  • dog(475580) HtrA serine peptidase 4

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