HTR2C
5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
Synonyms:
5-HT2C, 5-HTR2C, HTR1C
Species:
Human HTR2C (3358), Mouse Htr2c (15560), Rat Htr2c (25187), domestic cat HTR2C (101099620), naked mole-rat Htr2c (101726296), Horse HTR2C (100057852), cow HTR2C (538909), dog HTR2C (450240), chicken HTR2C (428707)
UniProtKB ID:
Gene ID:
- Human(3358) Summary: Serotonin (5-hydroxytryptamine, 5-HT), a neurotransmitter, elicits a wide array of physiological effects by binding to several receptor subtypes, including the 5-HT2 family of seven-transmembrane-spanning, G-protein-coupled receptors, which activate phospholipase C and D signaling pathways. This gene encodes the 2C subtype of serotonin receptor and its mRNA is subject to multiple RNA editing events, where genomically encoded adenosine residues are converted to inosines. RNA editing is predicted to alter amino acids within the second intracellular loop of the 5-HT2C receptor and generate receptor isoforms that differ in their ability to interact with G proteins and the activation of phospholipase C and D signaling cascades, thus modulating serotonergic neurotransmission in the central nervous system. Studies in humans have reported abnormalities in patterns of 5-HT2C editing in depressed suicide victims. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]
- Mouse(15560) 5-hydroxytryptamine (serotonin) receptor 2C
- Rat(25187) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
- domestic cat(101099620) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
- naked mole-rat(101726296) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
- Horse(100057852) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
- cow(538909) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
- dog(450240) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
- chicken(428707) 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
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Small Molecule - Antagonist
Product Number
Description
Species
Quetiapine for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
Amisulpride for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
Small Molecule - Inhibitor
Product Number
Description
Species
Small Molecule - Mixed Agonist/Antagonist
Product Number
Description
Species
Proteins
Product Number
Description
Species
ChemiSCREEN Human 5-HT2C Receptor Membrane Preparation, Human 5-HT2C GPCR membrane preparation for Radioligand binding Assays & GTPγS binding.,
Species
human