HSD3B7
hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
Synonyms:
CBAS1, PFIC4, SDR11E3
Species:
Human HSD3B7 (80270), Mouse Hsd3b7 (101502), Rat Hsd3b7 (246211), domestic cat HSD3B7 (101090824), dog HSD3B7 (489917), sheep HSD3B7 (101105716), cow HSD3B7 (540229), naked mole-rat Hsd3b7 (101708818), domestic guinea pig Hsd3b7 (100716211), chicken HSD3B7 (417505)
UniProtKB ID:
Gene ID:
- Human(80270) Summary: This gene encodes an enzyme which is involved in the initial stages of the synthesis of bile acids from cholesterol and a member of the short-chain dehydrogenase/reductase superfamily. The encoded protein is a membrane-associated endoplasmic reticulum protein which is active against 7-alpha hydrosylated sterol substrates. Mutations in this gene are associated with a congenital bile acid synthesis defect which leads to neonatal cholestasis, a form of progressive liver disease. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]
- Mouse(101502) hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
- Rat(246211) hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
- domestic cat(101090824) hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
- dog(489917) hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
- sheep(101105716) hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
- cow(540229) hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
- naked mole-rat(101708818) hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
- domestic guinea pig(100716211) hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
- chicken(417505) hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
- Zebrafish(327462) hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.