HIF1A
hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Synonyms:
HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78
Species:
Human HIF1A (3091), Mouse Hif1a (15251), Rat Hif1a (29560), dog HIF1A (480348), domestic guinea pig Hif1a (100713113), naked mole-rat Hif1a (101715845), Domestic Rabbit HIF1A (100009579), sheep HIF1A (443519), cow HIF1A (281814), domestic cat HIF1A (101083686)
UniProtKB ID:
Gene ID:
- Human(3091) Summary: This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]
- Mouse(15251) hypoxia inducible factor 1, alpha subunit
- Rat(29560) hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
- dog(480348) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
- domestic guinea pig(100713113) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
- naked mole-rat(101715845) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
- Domestic Rabbit(100009579) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
- sheep(443519) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
- cow(281814) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
- domestic cat(101083686) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
- chicken(374177) hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
Custom & Knockdown Gene Products
siRNA
Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.
shRNA
Shop the largest, most validated shRNA collection and build your own clone sets.
Custom Gene Products
We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.
ELISA
Product Number
Description
Species
Human HIF-1 alpha ELISA Kit, for cell culture supernatants, plasma, and serum samples,
Species
human
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Hypoxia Inducible Factor 1 α Antibody, clone H1α67, clone H1alpha67, Chemicon®, from mouse,
Species Reactivity
ferret, human, mouse, rat
Application
electrophoretic mobility shift assay
immunohistochemistry
immunoprecipitation (IP)
western blot
immunohistochemistry
immunoprecipitation (IP)
western blot