GRM2
glutamate receptor, metabotropic 2
Synonyms:
GLUR2, GPRC1B, MGLUR2, mGlu2
Species:
Human GRM2 (2912), Mouse Grm2 (108068), Rat Grm2 (24415), domestic guinea pig Grm2 (100720736), naked mole-rat Grm2 (101722804), chicken GRM2 (427575), dog GRM2 (484751), Horse GRM2 (100052178), domestic cat GRM2 (101098611), cow GRM2 (519904)
UniProtKB ID:
Gene ID:
- Human(2912) Summary: L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(108068) glutamate receptor, metabotropic 2
- Rat(24415) glutamate receptor, metabotropic 2
- domestic guinea pig(100720736) glutamate receptor, metabotropic 2
- naked mole-rat(101722804) glutamate receptor, metabotropic 2
- chicken(427575) glutamate receptor, metabotropic 2
- dog(484751) glutamate receptor, metabotropic 2
- Horse(100052178) glutamate receptor, metabotropic 2
- domestic cat(101098611) glutamate receptor, metabotropic 2
- cow(519904) glutamate receptor, metabotropic 2
- sheep(101116870) glutamate receptor, metabotropic 2
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-mGluR2/3 Antibody, Upstate®, from rabbit,
Species Reactivity
human, rat
Application
immunohistochemistry
immunoprecipitation (IP)
western blot
immunoprecipitation (IP)
western blot
Anti-Metabotropic Glutamate Receptor 2 Antibody, Chemicon®, from rabbit,
Species Reactivity
human
Application
immunocytochemistry
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-Metabotropic Glutamate Receptor 2/3 Antibody, Chemicon®, from rabbit,
Species Reactivity
monkey, rat
Application
immunohistochemistry
western blot
western blot