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Merck

GCLC

glutamate-cysteine ligase, catalytic subunit

Synonyms:
GCL, GCS, GLCL, GLCLC
Species:
Human GCLC (2729), Mouse Gclc (14629), Rat Gclc (25283), fruit fly Gclc (53581), Zebrafish gclc (326857), dog GCLC (609822), domestic guinea pig Gclc (100726181), naked mole-rat Gclc (101718793), Domestic Rabbit GCLC (100342383), cow GCLC (512468) ...More
UniProtKB ID:
P48506, Q14399
Gene ID:
  • Human(2729) Summary: Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase is the first rate-limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. This locus encodes the catalytic subunit, while the regulatory subunit is derived from a different gene located on chromosome 1p22-p21. Mutations at this locus have been associated with hemolytic anemia due to deficiency of gamma-glutamylcysteine synthetase and susceptibility to myocardial infarction.[provided by RefSeq, Oct 2010]
  • Mouse(14629) glutamate-cysteine ligase, catalytic subunit
  • Rat(25283) glutamate-cysteine ligase, catalytic subunit
  • fruit fly(53581) Glutamate-cysteine ligase catalytic subunit
  • Zebrafish(326857) glutamate-cysteine ligase, catalytic subunit
  • dog(609822) glutamate-cysteine ligase, catalytic subunit
  • domestic guinea pig(100726181) glutamate-cysteine ligase, catalytic subunit
  • naked mole-rat(101718793) glutamate-cysteine ligase, catalytic subunit
  • Domestic Rabbit(100342383) glutamate-cysteine ligase, catalytic subunit
  • cow(512468) glutamate-cysteine ligase, catalytic subunit
  • sheep(101114822) glutamate-cysteine ligase, catalytic subunit
  • domestic cat(101096568) glutamate-cysteine ligase, catalytic subunit
  • Horse(100056731) glutamate-cysteine ligase, catalytic subunit
  • chicken(421894) glutamate-cysteine ligase, catalytic subunit

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