FOXP2
forkhead box P2
Synonyms:
CAGH44, SPCH1, TNRC10
Species:
Human FOXP2 (93986), Mouse Foxp2 (114142), Rat Foxp2 (500037), domestic cat FOXP2 (100134847), dog FOXP2 (482413), Domestic Rabbit FOXP2 (100328793), naked mole-rat Foxp2 (101699542), chicken FOXP2 (769935), Zebrafish foxp2 (555242), sheep FOXP2 (101110051) ...More
UniProtKB ID:
Gene ID:
- Human(93986) Summary: This gene encodes a member of the forkhead/winged-helix (FOX) family of transcription factors. It is expressed in fetal and adult brain as well as in several other organs such as the lung and gut. The protein product contains a FOX DNA-binding domain and a large polyglutamine tract and is an evolutionarily conserved transcription factor, which may bind directly to approximately 300 to 400 gene promoters in the human genome to regulate the expression of a variety of genes. This gene is required for proper development of speech and language regions of the brain during embryogenesis, and may be involved in a variety of biological pathways and cascades that may ultimately influence language development. Mutations in this gene cause speech-language disorder 1 (SPCH1), also known as autosomal dominant speech and language disorder with orofacial dyspraxia. Multiple alternative transcripts encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010]
- Mouse(114142) forkhead box P2
- Rat(500037) forkhead box P2
- domestic cat(100134847) forkhead box P2
- dog(482413) forkhead box P2
- Domestic Rabbit(100328793) forkhead box P2
- naked mole-rat(101699542) forkhead box P2
- chicken(769935) forkhead box P2
- Zebrafish(555242) forkhead box P2
- sheep(101110051) forkhead box P2
- domestic guinea pig(100717297) forkhead box P2
- Goat(100860795) forkhead box P2
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