FGF8
fibroblast growth factor 8 (androgen-induced)
Synonyms:
AIGF, FGF-8, HBGF-8, HH6, KAL6
Species:
Human FGF8 (2253), Mouse Fgf8 (14179), Rat Fgf8 (29349), chicken FGF8 (396313), domestic cat FGF8 (101084652), dog FGF8 (403868), sheep FGF8 (101113716), cow FGF8 (326284), Domestic Rabbit FGF8 (100008834), naked mole-rat Fgf8 (101699438)
UniProtKB ID:
Gene ID:
- Human(2253) Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This protein is known to be a factor that supports androgen and anchorage independent growth of mammary tumor cells. Overexpression of this gene has been shown to increase tumor growth and angiogensis. The adult expression of this gene is restricted to testes and ovaries. Temporal and spatial pattern of this gene expression suggests its function as an embryonic epithelial factor. Studies of the mouse and chick homologs revealed roles in midbrain and limb development, organogenesis, embryo gastrulation and left-right axis determination. The alternative splicing of this gene results in four transcript variants. [provided by RefSeq, Jul 2008]
- Mouse(14179) fibroblast growth factor 8
- Rat(29349) fibroblast growth factor 8
- chicken(396313) fibroblast growth factor 8 (androgen-induced)
- domestic cat(101084652) fibroblast growth factor 8 (androgen-induced)
- dog(403868) fibroblast growth factor 8 (androgen-induced)
- sheep(101113716) fibroblast growth factor 8 (androgen-induced)
- cow(326284) fibroblast growth factor 8 (androgen-induced)
- Domestic Rabbit(100008834) fibroblast growth factor 8 (androgen-induced)
- naked mole-rat(101699438) fibroblast growth factor 8 (androgen-induced)
- domestic guinea pig(100721355) fibroblast growth factor 8 (androgen-induced)
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