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Merck

FEN1

flap structure-specific endonuclease 1

Synonyms:
FEN-1, MF1, RAD2
Species:
Human FEN1 (2237), Mouse Fen1 (14156), Rat Fen1 (84490), Zebrafish fen1 (386707), fruit fly Fen1 (36887), domestic guinea pig Fen1 (100723622), naked mole-rat Fen1 (101698770), Domestic Rabbit FEN1 (100352966), sheep FEN1 (100307042), chicken FEN1 (769677) ...More
UniProtKB ID:
P39748
Gene ID:
  • Human(2237) Summary: The protein encoded by this gene removes 5' overhanging flaps in DNA repair and processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis. Direct physical interaction between this protein and AP endonuclease 1 during long-patch base excision repair provides coordinated loading of the proteins onto the substrate, thus passing the substrate from one enzyme to another. The protein is a member of the XPG/RAD2 endonuclease family and is one of ten proteins essential for cell-free DNA replication. DNA secondary structure can inhibit flap processing at certain trinucleotide repeats in a length-dependent manner by concealing the 5' end of the flap that is necessary for both binding and cleavage by the protein encoded by this gene. Therefore, secondary structure can deter the protective function of this protein, leading to site-specific trinucleotide expansions. [provided by RefSeq, Jul 2008]
  • Mouse(14156) flap structure specific endonuclease 1
  • Rat(84490) flap structure-specific endonuclease 1
  • Zebrafish(386707) flap structure-specific endonuclease 1
  • fruit fly(36887) Flap endonuclease 1
  • domestic guinea pig(100723622) flap structure-specific endonuclease 1
  • naked mole-rat(101698770) flap structure-specific endonuclease 1
  • Domestic Rabbit(100352966) flap structure-specific endonuclease 1
  • sheep(100307042) flap structure-specific endonuclease 1
  • chicken(769677) flap structure-specific endonuclease 1
  • dog(476063) flap structure-specific endonuclease 1
  • Horse(100059838) flap structure-specific endonuclease 1
  • domestic cat(101083708) flap structure-specific endonuclease 1
  • cow(616242) flap structure-specific endonuclease 1

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