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Merck

FCGR3A

Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

Synonyms:
CD16, CD16A, FCG3, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA, IGFR3
Species:
Human FCGR3A (2214), Rat Fcgr3a (304966), dog FCGR3A (478984), sheep FCGR3A (100192433), cow FCGR3A (281766)
UniProtKB ID:
P08637, A2N6W9, Q53FJ0, Q53FL6, Q5EBR4, Q65ZM6, Q6PIJ0
Gene ID:
  • Human(2214) Summary: This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
  • Rat(304966) Fc fragment of IgG, low affinity IIIa, receptor
  • dog(478984) Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
  • sheep(100192433) Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
  • cow(281766) Fc fragment of IgG, low affinity IIIa, receptor (CD16a)

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