FBLN5
fibulin 5
Synonyms:
ADCL2, ARCL1A, ARMD3, DANCE, EVEC, FIBL-5, UP50
Species:
Human FBLN5 (10516), Mouse Fbln5 (23876), Rat Fbln5 (29158), Horse FBLN5 (100063331), cow FBLN5 (535185), naked mole-rat Fbln5 (101709553), domestic cat FBLN5 (101096324), dog FBLN5 (480227), Domestic Rabbit FBLN5 (100347343), domestic guinea pig Fbln5 (100715192) ...More
UniProtKB ID:
Gene ID:
- Human(10516) Summary: The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3). [provided by RefSeq, Jul 2008]
- Mouse(23876) fibulin 5
- Rat(29158) fibulin 5
- Horse(100063331) fibulin 5
- cow(535185) fibulin 5
- naked mole-rat(101709553) fibulin 5
- domestic cat(101096324) fibulin 5
- dog(480227) fibulin 5
- Domestic Rabbit(100347343) fibulin 5
- domestic guinea pig(100715192) fibulin 5
- Zebrafish(449806) fibulin 5
- sheep(101112927) fibulin 5
- chicken(423413) fibulin 5
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