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Merck

F10

coagulation factor X

Synonyms:
FX, FXA
Species:
Human F10 (2159), Mouse F10 (14058), Rat F10 (29243), chicken F10 (395876), Zebrafish f10 (282670), naked mole-rat F10 (101706544), domestic guinea pig F10 (100726878), Domestic Rabbit F10 (100008647), sheep F10 (101118624), cow F10 (790178) ...More
UniProtKB ID:
P00742, Q14340
Gene ID:
  • Human(2159) Summary: This gene encodes the vitamin K-dependent coagulation factor X of the blood coagulation cascade. This factor undergoes multiple processing steps before its preproprotein is converted to a mature two-chain form by the excision of the tripeptide RKR. Two chains of the factor are held together by 1 or more disulfide bonds; the light chain contains 2 EGF-like domains, while the heavy chain contains the catalytic domain which is structurally homologous to those of the other hemostatic serine proteases. The mature factor is activated by the cleavage of the activation peptide by factor IXa (in the intrisic pathway), or by factor VIIa (in the extrinsic pathway). The activated factor then converts prothrombin to thrombin in the presence of factor Va, Ca+2, and phospholipid during blood clotting. Mutations of this gene result in factor X deficiency, a hemorrhagic condition of variable severity. [provided by RefSeq, Jul 2008]
  • Mouse(14058) coagulation factor X
  • Rat(29243) coagulation factor X
  • chicken(395876) coagulation factor X
  • Zebrafish(282670) coagulation factor X
  • naked mole-rat(101706544) coagulation factor X
  • domestic guinea pig(100726878) coagulation factor X
  • Domestic Rabbit(100008647) coagulation factor X
  • sheep(101118624) coagulation factor X
  • cow(790178) coagulation factor X-like
  • cow(280787) coagulation factor X
  • domestic cat(101098029) coagulation factor X
  • dog(476993) coagulation factor X

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