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Merck

EGFR

epidermal growth factor receptor

Synonyms:
ERBB, ERBB1, HER1, PIG61, mENA
Species:
UniProtKB ID:
Gene ID:
  • Human(1956) Summary: The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer. Multiple alternatively spliced transcript variants that encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
  • Mouse(13649) epidermal growth factor receptor
  • Rat(24329) epidermal growth factor receptor
  • sheep(780479) epidermal growth factor receptor
  • domestic guinea pig(100725363) epidermal growth factor receptor
  • dog(404306) epidermal growth factor receptor
  • fruit fly(37455) Epidermal growth factor receptor
  • Horse(100067755) epidermal growth factor receptor
  • cow(407217) epidermal growth factor receptor
  • naked mole-rat(101723771) epidermal growth factor receptor
  • domestic cat(100510799) epidermal growth factor receptor
  • chicken(396494) epidermal growth factor receptor

Custom & Knockdown Gene Products

ELISA

Product Number
Description
Species
Cell-Based ELISA for detecting phospho-EGFR (pTyr992) in cultured cell lines, 96 assays,
Species
human
Phospho-EGFR (pTyr1045) ELISA Kit, for detection of human phospho-egfr (pTyr1045) in cell and tissue lysates,
Species
human
Mouse EGFR ELISA, for serum, plasma and cell culture supernatants,
Species
mouse
Phospho-EGFR (pTyr1068) ELISA Kit, for detection of human phospho-egfr (pTyr1068) in cell and tissue lysates,
Species
human
Phospho-EGFR (pTyr1068) and pan-EGFR ELISA Kit, for detection of human phospho-egfr (pTyr1068) and pan-egfr in cell and tissue lysates,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Genistein, synthetic, ≥98% (HPLC), powder,
Species
mouse, human, rat

Antibodies

Product Number
Description
Species Reactivity
Application
Monoclonal Anti-Epidermal Growth Factor Receptor antibody produced in mouse, clone F4, ascites fluid,
Species Reactivity
human
Application
ELISA
immunohistochemistry

immunoprecipitation (IP)

microarray

western blot
Anti-phospho-EGFR (Tyr1148) Antibody, Upstate®, from rabbit,
Species Reactivity
human
Application
western blot
Anti-EGFR antibody, Rabbit monoclonal, clone SP84, recombinant, expressed in proprietary host, affinity isolated antibody,
Species Reactivity
bovine, frog, human, mouse, pig, rat
Application
immunohistochemistry
western blot
Anti-phospho-EGFR (Tyr845) Antibody, Upstate®, from rabbit,
Species Reactivity
human
Application
immunocytochemistry
immunofluorescence

immunohistochemistry

western blot
Milli-Mark® Anti-EGFR-FITC Antibody, Milli-Mark®, from rabbit,
Species Reactivity
human
Application
flow cytometry

Small Molecule - Inhibitor

Product Number
Description
Species
Gefitinib for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
Gefitinib, European Pharmacopoeia (EP) Reference Standard,
Species
human
Genistein, synthetic, ≥98% (HPLC), powder,
Species
mouse, human, rat