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Merck

E2F1

E2F transcription factor 1

Synonyms:
E2F-1, RBAP1, RBBP3, RBP3
Species:
Human E2F1 (1869), Mouse E2f1 (13555), Rat E2f1 (399489), chicken E2F1 (396142), Thale Cress E2F1 (832283), naked mole-rat E2f1 (101717980), Horse E2F1 (100069192), cow E2F1 (535369), sheep E2F1 (101117526), dog E2F1 (485839) ...More
UniProtKB ID:
Q01094, Q13143, Q92768
Gene ID:
  • Human(1869) Summary: The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis. [provided by RefSeq, Jul 2008]
  • Mouse(13555) E2F transcription factor 1
  • Rat(399489) E2F transcription factor 1
  • chicken(396142) E2F transcription factor 1
  • Thale Cress(832283) E2F transcription factor 1
  • naked mole-rat(101717980) E2F transcription factor 1
  • Horse(100069192) E2F transcription factor 1
  • cow(535369) E2F transcription factor 1
  • sheep(101117526) E2F transcription factor 1
  • dog(485839) E2F transcription factor 1
  • domestic guinea pig(100729531) E2F transcription factor 1
  • domestic cat(101098454) E2F transcription factor 1

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Antibodies

Product Number
Description
Species Reactivity
Application
05-379
Anti-E2F-1 Antibody, clones KH20 and KH95, Upstate®, from mouse,
Species Reactivity
xenopus, human
Application
immunoprecipitation (IP)
western blot