Skip to Content
Merck

DUSP4

dual specificity phosphatase 4

Synonyms:
HVH2, MKP-2, MKP2, TYP
Species:
Human DUSP4 (1846), Mouse Dusp4 (319520), Rat Dusp4 (60587), domestic guinea pig Dusp4 (100728293), cow DUSP4 (540380), domestic cat DUSP4 (101088832), Domestic Rabbit DUSP4 (100351542), sheep DUSP4 (101103535), chicken DUSP4 (395642), Zebrafish dusp4 (394146)
UniProtKB ID:
Q13115, B2RBU5, D3DSU4, G5E930, Q13524
Gene ID:
  • Human(1846) Summary: The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product inactivates ERK1, ERK2 and JNK, is expressed in a variety of tissues, and is localized in the nucleus. Two alternatively spliced transcript variants, encoding distinct isoforms, have been observed for this gene. In addition, multiple polyadenylation sites have been reported. [provided by RefSeq, Jul 2008]
  • Mouse(319520) dual specificity phosphatase 4
  • Rat(60587) dual specificity phosphatase 4
  • domestic guinea pig(100728293) dual specificity phosphatase 4
  • cow(540380) dual specificity phosphatase 4
  • domestic cat(101088832) dual specificity phosphatase 4
  • Domestic Rabbit(100351542) dual specificity phosphatase 4
  • sheep(101103535) dual specificity phosphatase 4
  • chicken(395642) dual specificity phosphatase 4
  • Zebrafish(394146) dual specificity phosphatase 4
  • dog(482880) dual specificity phosphatase 4

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.