DUSP1
dual specificity phosphatase 1
Synonyms:
CL100, HVH1, MKP-1, MKP1, PTPN10
Species:
Human DUSP1 (1843), Mouse Dusp1 (19252), Rat Dusp1 (114856), Domestic Rabbit DUSP1 (100340993), sheep DUSP1 (101107632), naked mole-rat Dusp1 (101701425), domestic guinea pig Dusp1 (100725668), chicken DUSP1 (374192), Zebrafish dusp1 (406340), dog DUSP1 (489117) ...More
UniProtKB ID:
Gene ID:
- Human(1843) Summary: The expression of DUSP1 gene is induced in human skin fibroblasts by oxidative/heat stress and growth factors. It specifies a protein with structural features similar to members of the non-receptor-type protein-tyrosine phosphatase family, and which has significant amino-acid sequence similarity to a Tyr/Ser-protein phosphatase encoded by the late gene H1 of vaccinia virus. The bacterially expressed and purified DUSP1 protein has intrinsic phosphatase activity, and specifically inactivates mitogen-activated protein (MAP) kinase in vitro by the concomitant dephosphorylation of both its phosphothreonine and phosphotyrosine residues. Furthermore, it suppresses the activation of MAP kinase by oncogenic ras in extracts of Xenopus oocytes. Thus, DUSP1 may play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. [provided by RefSeq, Jul 2008]
- Mouse(19252) dual specificity phosphatase 1
- Rat(114856) dual specificity phosphatase 1
- Domestic Rabbit(100340993) dual specificity phosphatase 1
- sheep(101107632) dual specificity phosphatase 1
- naked mole-rat(101701425) dual specificity phosphatase 1
- domestic guinea pig(100725668) dual specificity phosphatase 1
- chicken(374192) dual specificity phosphatase 1
- Zebrafish(406340) dual specificity phosphatase 1
- dog(489117) dual specificity phosphatase 1
- cow(539175) dual specificity phosphatase 1
- domestic cat(101093416) dual specificity phosphatase 1
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