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Merck

DR1

down-regulator of transcription 1, TBP-binding (negative cofactor 2)

Synonyms:
NC2, NC2-BETA
Species:
Human DR1 (1810), Mouse Dr1 (13486), Rat Dr1 (289881), Zebrafish dr1 (768171), chicken DR1 (424496), cow DR1 (613828), domestic cat DR1 (101098807), dog DR1 (479943), sheep DR1 (101105865), naked mole-rat Dr1 (101707064)
UniProtKB ID:
Q01658
Gene ID:
  • Human(1810) Summary: This gene encodes a TBP- (TATA box-binding protein) associated phosphoprotein that represses both basal and activated levels of transcription. The encoded protein is phosphorylated in vivo and this phosphorylation affects its interaction with TBP. This protein contains a histone fold motif at the amino terminus, a TBP-binding domain, and a glutamine- and alanine-rich region. The binding of DR1 repressor complexes to TBP-promoter complexes may establish a mechanism in which an altered DNA conformation, together with the formation of higher order complexes, inhibits the assembly of the preinitiation complex and controls the rate of RNA polymerase II transcription. [provided by RefSeq, Jul 2008]
  • Mouse(13486) down-regulator of transcription 1
  • Rat(289881) down-regulator of transcription 1
  • Zebrafish(768171) down-regulator of transcription 1
  • chicken(424496) down-regulator of transcription 1, TBP-binding (negative cofactor 2)
  • cow(613828) down-regulator of transcription 1, TBP-binding (negative cofactor 2)
  • domestic cat(101098807) down-regulator of transcription 1, TBP-binding (negative cofactor 2)
  • dog(479943) down-regulator of transcription 1, TBP-binding (negative cofactor 2)
  • sheep(101105865) down-regulator of transcription 1, TBP-binding (negative cofactor 2)
  • naked mole-rat(101707064) down-regulator of transcription 1, TBP-binding (negative cofactor 2)
  • domestic guinea pig(100724062) down-regulator of transcription 1, TBP-binding (negative cofactor 2)

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