DHCR24
24-dehydrocholesterol reductase
Synonyms:
DCE, Nbla03646, SELADIN1, seladin-1
Species:
Human DHCR24 (1718), Mouse Dhcr24 (74754), Rat Dhcr24 (298298), domestic guinea pig Dhcr24 (100714000), naked mole-rat Dhcr24 (101703975), dog DHCR24 (489573), domestic cat DHCR24 (101098730), Horse DHCR24 (100034055), cow DHCR24 (533726), sheep DHCR24 (101123162) ...More
UniProtKB ID:
Gene ID:
- Human(1718) Summary: This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells. [provided by RefSeq, Jul 2008]
- Mouse(74754) 24-dehydrocholesterol reductase
- Rat(298298) 24-dehydrocholesterol reductase
- domestic guinea pig(100714000) 24-dehydrocholesterol reductase
- naked mole-rat(101703975) 24-dehydrocholesterol reductase
- dog(489573) 24-dehydrocholesterol reductase
- domestic cat(101098730) 24-dehydrocholesterol reductase
- Horse(100034055) 24-dehydrocholesterol reductase
- cow(533726) 24-dehydrocholesterol reductase
- sheep(101123162) 24-dehydrocholesterol reductase
- Zebrafish(494102) 24-dehydrocholesterol reductase
- chicken(424661) 24-dehydrocholesterol reductase
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