CYP3A4
cytochrome P450, family 3, subfamily A, polypeptide 4
Synonyms:
CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1
Species:
Human CYP3A4 (1576), Horse CYP3A4 (100294525), cow CYP3A4 (507988), dog CYP3A4 (479740), chicken CYP3A4 (416477)
UniProtKB ID:
Gene ID:
- Human(1576) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by glucocorticoids and some pharmacological agents. This enzyme is involved in the metabolism of approximately half the drugs in use today, including acetaminophen, codeine, cyclosporin A, diazepam and erythromycin. The enzyme also metabolizes some steroids and carcinogens. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Previously another CYP3A gene, CYP3A3, was thought to exist; however, it is now thought that this sequence represents a transcript variant of CYP3A4. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Feb 2011]
- Horse(100294525) cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
- cow(507988) cytochrome P450, subfamily IIIA, polypeptide 4
- dog(479740) cytochrome P450, family 3, subfamily A, polypeptide 4
- chicken(416477) cytochrome P450, family 3, subfamily A, polypeptide 4
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Cytochrome P450 Enzyme CYP3A4 Antibody, serum, Chemicon®,
Species Reactivity
human, mammals, pig, rat
Application
immunohistochemistry
western blot
western blot