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Merck

CYP2C19

cytochrome P450, family 2, subfamily C, polypeptide 19

Synonyms:
CPCJ, CYP2C, P450C2C, P450IIC19
Species:
Human CYP2C19 (1557), sheep CYP2C19 (100534653), cow CYP2C19 (510380)
UniProtKB ID:
P33261, P33259, Q8WZB1, Q8WZB2, Q9UCD4
Gene ID:
  • Human(1557) Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, omeprazole, diazepam and some barbiturates. Polymorphism within this gene is associated with variable ability to metabolize mephenytoin, known as the poor metabolizer and extensive metabolizer phenotypes. The gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. [provided by RefSeq, Jul 2008]
  • sheep(100534653) cytochrome P450 2C19
  • cow(510380) cytochrome P450, family 2, subfamily C, polypeptide 19

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