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Merck

CXCR4

chemokine (C-X-C motif) receptor 4

Synonyms:
CD184, D2S201E, FB22, HM89, HSY3RR, LAP3, LCR1, LESTR, NPY3R, NPYR, NPYRL, NPYY3R, WHIM
Species:
Human CXCR4 (7852), Mouse Cxcr4 (12767), Rat Cxcr4 (60628), cow CXCR4 (281736), domestic guinea pig Cxcr4 (100731341), dog CXCR4 (483900), naked mole-rat Cxcr4 (101699254), sheep CXCR4 (443532), chicken CXCR4 (395324), Domestic Rabbit CXCR4 (100346189)
UniProtKB ID:
P61073, B2R5N0, O60835, P30991, P56438, Q53S69, Q9BXA0, Q9UKN2
Gene ID:
  • Human(7852) Summary: This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
  • Mouse(12767) chemokine (C-X-C motif) receptor 4
  • Rat(60628) chemokine (C-X-C motif) receptor 4
  • cow(281736) chemokine (C-X-C motif) receptor 4
  • domestic guinea pig(100731341) chemokine (C-X-C motif) receptor 4
  • dog(483900) chemokine (C-X-C motif) receptor 4
  • naked mole-rat(101699254) chemokine (C-X-C motif) receptor 4
  • sheep(443532) neuropeptide Y receptor type 3
  • chicken(395324) chemokine (C-X-C motif) receptor 4
  • Domestic Rabbit(100346189) chemokine (C-X-C motif) receptor 4
  • domestic cat(493676) chemokine (C-X-C motif) receptor 4

Custom & Knockdown Gene Products

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Antibodies

Product Number
Description
Species Reactivity
Application
AB1846
Anti-C-X-C Chemokine Receptor 4 Antibody, NT, Chemicon®, from rabbit,
Species Reactivity
human
Application
immunocytochemistry
immunoprecipitation (IP)
western blot
AB1847
Anti-C-X-C Chemokine Receptor 4 Antibody, extracellular loop, Chemicon®, from rabbit,
Species Reactivity
human, mouse
Application
western blot

Proteins

Product Number
Description
Species
HTS004M
ChemiSCREEN CXCR4 Membrane Preparation, Human CXCR4 GPCR membrane preparation for Radioligand binding Assays & GTPgammaS binding.,
Species
human