CTSB
cathepsin B
Synonyms:
APPS, CPSB
Species:
Human CTSB (1508), Mouse Ctsb (13030), Rat Ctsb (64529), domestic guinea pig Ctsb (100714169), naked mole-rat Ctsb (101709008), dog CTSB (486077), Horse CTSB (100060963), domestic cat CTSB (101084873), cow CTSB (281105), sheep CTSB (780470)
UniProtKB ID:
Gene ID:
- Human(1508) Summary: The protein encoded by this gene is a lysosomal cysteine proteinase composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer disease, the most common cause of dementia. Overexpression of the encoded protein, which is a member of the peptidase C1 family, has been associated with esophageal adenocarcinoma and other tumors. At least five transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
- Mouse(13030) cathepsin B
- Rat(64529) cathepsin B
- domestic guinea pig(100714169) cathepsin B
- naked mole-rat(101709008) cathepsin B
- dog(486077) cathepsin B
- Horse(100060963) cathepsin B
- domestic cat(101084873) cathepsin B
- cow(281105) cathepsin B
- sheep(780470) cathepsin B
- chicken(396329) cathepsin B
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