CSTB
cystatin B (stefin B)
Synonyms:
CST6, EPM1, EPM1A, PME, STFB, ULD
Species:
Human CSTB (1476), Mouse Cstb (13014), Rat Cstb (25308), domestic guinea pig Cstb (100719016), naked mole-rat Cstb (101699171), cow CSTB (514170), cow CSTB (512805), dog CSTB (478424), chicken CSTB (418267), sheep CSTB (101123265)
UniProtKB ID:
Gene ID:
- Human(1476) Summary: The cystatin superfamily encompasses proteins that contain multiple cystatin-like sequences. Some of the members are active cysteine protease inhibitors, while others have lost or perhaps never acquired this inhibitory activity. There are three inhibitory families in the superfamily, including the type 1 cystatins (stefins), type 2 cystatins and kininogens. This gene encodes a stefin that functions as an intracellular thiol protease inhibitor. The protein is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. The protein is thought to play a role in protecting against the proteases leaking from lysosomes. Evidence indicates that mutations in this gene are responsible for the primary defects in patients with progressive myoclonic epilepsy (EPM1). [provided by RefSeq, Jul 2008]
- Mouse(13014) cystatin B
- Rat(25308) cystatin B (stefin B)
- domestic guinea pig(100719016) cystatin B (stefin B)
- naked mole-rat(101699171) cystatin B (stefin B)
- cow(514170) cystatin B (stefin B)
- cow(512805) cystatin B (stefin B)
- dog(478424) cystatin B (stefin B)
- chicken(418267) cystatin B (stefin B)
- sheep(101123265) cystatin B (stefin B)
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