CSF1R
colony stimulating factor 1 receptor
Synonyms:
C-FMS, CD115, CSF-1R, CSFR, FIM2, FMS, HDLS, M-CSF-R
Species:
Human CSF1R (1436), Mouse Csf1r (12978), Rat Csf1r (307403), domestic guinea pig Csf1r (100726053), naked mole-rat Csf1r (101719513), sheep CSF1R (101109969), cow CSF1R (509418), domestic cat CSF1R (493706), Horse CSF1R (100060422), dog CSF1R (489188)
UniProtKB ID:
Gene ID:
- Human(1436) Summary: The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. [provided by RefSeq, Jul 2008]
- Mouse(12978) colony stimulating factor 1 receptor
- Rat(307403) colony stimulating factor 1 receptor
- domestic guinea pig(100726053) colony stimulating factor 1 receptor
- naked mole-rat(101719513) colony stimulating factor 1 receptor
- sheep(101109969) colony stimulating factor 1 receptor
- cow(509418) colony stimulating factor 1 receptor
- domestic cat(493706) colony stimulating factor 1 receptor
- Horse(100060422) colony stimulating factor 1 receptor
- dog(489188) colony stimulating factor 1 receptor
- chicken(396406) colony stimulating factor 1 receptor
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