COX6A1
cytochrome c oxidase subunit VIa polypeptide 1
Synonyms:
COX6A, COX6AL
Species:
Human COX6A1 (1337), Mouse Cox6a1 (12861), Rat Cox6a1 (25282), chicken COX6A1 (416978), Zebrafish cox6a1 (335774), Domestic Rabbit COX6A1 (100327270), cow COX6A1 (282199)
UniProtKB ID:
Gene ID:
- Human(1337) Summary: Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in the electron transfer and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes polypeptide 1 (liver isoform) of subunit VIa, and polypeptide 1 is found in all non-muscle tissues. Polypeptide 2 (heart/muscle isoform) of subunit VIa is encoded by a different gene, and is present only in striated muscles. These two polypeptides share 66% amino acid sequence identity. It has been reported that there may be several pseudogenes on chromosomes 1, 6, 7q21, 7q31-32 and 12. However, only one pseudogene (COX6A1P) on chromosome 1p31.1 has been documented. [provided by RefSeq, Jul 2008]
- Mouse(12861) cytochrome c oxidase subunit VIa polypeptide 1
- Rat(25282) cytochrome c oxidase, subunit VIa, polypeptide 1
- chicken(416978) cytochrome c oxidase subunit VIa polypeptide 1
- Zebrafish(335774) cytochrome c oxidase subunit VIa polypeptide 1
- Domestic Rabbit(100327270) cytochrome c oxidase subunit VIa
- cow(282199) cytochrome c oxidase subunit VIa polypeptide 1
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