COL4A3
collagen, type IV, alpha 3 (Goodpasture antigen)
Synonyms:
Species:
Human COL4A3 (1285), Mouse Col4a3 (12828), Rat Col4a3 (363265), chicken COL4A3 (424797), cow COL4A3 (317711), domestic cat COL4A3 (101087512), Zebrafish col4a3 (553354), dog COL4A3 (403842), Horse COL4A3 (100037402), naked mole-rat Col4a3 (101709004) ...More
UniProtKB ID:
Gene ID:
- Human(1285) Summary: Type IV collagen, the major structural component of basement membranes, is a multimeric protein composed of 3 alpha subunits. These subunits are encoded by 6 different genes, alpha 1 through alpha 6, each of which can form a triple helix structure with 2 other subunits to form type IV collagen. This gene encodes alpha 3. In the Goodpasture syndrome, autoantibodies bind to the collagen molecules in the basement membranes of alveoli and glomeruli. The epitopes that elicit these autoantibodies are localized largely to the non-collagenous C-terminal domain of the protein. A specific kinase phosphorylates amino acids in this same C-terminal region and the expression of this kinase is upregulated during pathogenesis. This gene is also linked to an autosomal recessive form of Alport syndrome. The mutations contributing to this syndrome are also located within the exons that encode this C-terminal region. Like the other members of the type IV collagen gene family, this gene is organized in a head-to-head conformation with another type IV collagen gene so that each gene pair shares a common promoter. [provided by RefSeq, Jun 2010]
- Mouse(12828) collagen, type IV, alpha 3
- Rat(363265) collagen, type IV, alpha 3
- chicken(424797) collagen, type IV, alpha 3 (Goodpasture antigen)
- cow(317711) collagen, type IV, alpha 3 (Goodpasture antigen)
- domestic cat(101087512) collagen, type IV, alpha 3 (Goodpasture antigen)
- Zebrafish(553354) collagen, type IV, alpha 3
- dog(403842) collagen, type IV, alpha 3 (Goodpasture antigen)
- Horse(100037402) collagen, type IV, alpha 3 (Goodpasture antigen)
- naked mole-rat(101709004) collagen, type IV, alpha 3 (Goodpasture antigen)
- Domestic Rabbit(100009082) collagen, type IV, alpha 3 (Goodpasture antigen)
- sheep(443526) collagen, type IV, alpha 3 (Goodpasture antigen)
- domestic guinea pig(100732315) collagen, type IV, alpha 3 (Goodpasture antigen)
- sheep(101102790) collagen, type IV, alpha 3 (Goodpasture antigen)
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