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Merck

CLCN4

chloride channel, voltage-sensitive 4

Synonyms:
CLC4, ClC-4, ClC-4A
Species:
UniProtKB ID:
Gene ID:
  • Human(1183) Summary: The CLCN family of voltage-dependent chloride channel genes comprises nine members (CLCN1-7, Ka and Kb) which demonstrate quite diverse functional characteristics while sharing significant sequence homology. Chloride channel 4 has an evolutionary conserved CpG island and is conserved in both mouse and hamster. This gene is mapped in close proximity to APXL (Apical protein Xenopus laevis-like) and OA1 (Ocular albinism type I), which are both located on the human X chromosome at band p22.3. The physiological role of chloride channel 4 remains unknown but may contribute to the pathogenesis of neuronal disorders. Alternate splicing results in two transcript variants that encode different proteins. [provided by RefSeq, Mar 2012]
  • Rat(60586) chloride channel, voltage-sensitive 4
  • dog(491736) chloride channel, voltage-sensitive 4
  • chicken(428005) chloride channel 4
  • Horse(100049933) chloride channel, voltage-sensitive 4
  • Zebrafish(768175) chloride channel, voltage-sensitive 4
  • cow(511699) chloride channel 4
  • domestic cat(101088304) chloride channel, voltage-sensitive 4
  • naked mole-rat(101702325) chloride channel, voltage-sensitive 4
  • domestic guinea pig(100714722) chloride channel, voltage-sensitive 4

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