CFL1
cofilin 1 (non-muscle)
Synonyms:
CFL
Species:
Human CFL1 (1072), Mouse Cfl1 (12631), Rat Cfl1 (29271), sheep CFL1 (494432), dog CFL1 (476022), Zebrafish cfl1 (406738), cow CFL1 (534553), naked mole-rat Cfl1 (101713836), domestic cat CFL1 (101100251), domestic guinea pig Cfl1 (100732287)
UniProtKB ID:
Gene ID:
- Human(1072) Summary: The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]
- Mouse(12631) cofilin 1, non-muscle
- Rat(29271) cofilin 1, non-muscle
- sheep(494432) cofilin 1 (non-muscle)
- dog(476022) cofilin 1 (non-muscle)
- Zebrafish(406738) cofilin 1 (non-muscle)
- cow(534553) cofilin 1 (non-muscle)
- naked mole-rat(101713836) cofilin 1 (non-muscle)
- domestic cat(101100251) cofilin 1 (non-muscle)
- domestic guinea pig(100732287) cofilin 1 (non-muscle)
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