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Merck

CFHR1

complement factor H-related 1

Synonyms:
CFHL, CFHL1, CFHL1P, CFHR1P, FHR1, H36-1, H36-2, HFL1, HFL2
Species:
Human CFHR1 (3078), Mouse Cfhr1 (50702), Rat Cfhr1 (289057)
UniProtKB ID:
Q03591, A8K465, Q3B774, Q9UJ17
Gene ID:
  • Human(3078) Summary: This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009]
  • Mouse(50702) complement factor H-related 1
  • Rat(289057) complement factor H-related 1

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