CDKN1A
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Synonyms:
CAP20, CDKN1, CIP1, MDA-6, P21, SDI1, WAF1, p21CIP1
Species:
Human CDKN1A (1026), Mouse Cdkn1a (12575), Rat Cdkn1a (114851), Zebrafish cdkn1a (100151416), domestic guinea pig Cdkn1a (100720449), cow CDKN1A (513497), sheep CDKN1A (100302083), dog CDKN1A (474890), domestic cat CDKN1A (493943), naked mole-rat Cdkn1a (101710552)
UniProtKB ID:
Gene ID:
- Human(1026) Summary: This gene encodes a potent cyclin-dependent kinase inhibitor. The encoded protein binds to and inhibits the activity of cyclin-CDK2 or -CDK4 complexes, and thus functions as a regulator of cell cycle progression at G1. The expression of this gene is tightly controlled by the tumor suppressor protein p53, through which this protein mediates the p53-dependent cell cycle G1 phase arrest in response to a variety of stress stimuli. This protein can interact with proliferating cell nuclear antigen (PCNA), a DNA polymerase accessory factor, and plays a regulatory role in S phase DNA replication and DNA damage repair. This protein was reported to be specifically cleaved by CASP3-like caspases, which thus leads to a dramatic activation of CDK2, and may be instrumental in the execution of apoptosis following caspase activation. Multiple alternatively spliced variants have been found for this gene. [provided by RefSeq, Nov 2010]
- Mouse(12575) cyclin-dependent kinase inhibitor 1A (P21)
- Rat(114851) cyclin-dependent kinase inhibitor 1A
- Zebrafish(100151416) cyclin-dependent kinase inhibitor 1A
- domestic guinea pig(100720449) cyclin-dependent kinase inhibitor 1A (p21, Cip1)
- cow(513497) cyclin-dependent kinase inhibitor 1A (p21, Cip1)
- sheep(100302083) cyclin-dependent kinase inhibitor 1A (p21, Cip1)
- dog(474890) cyclin-dependent kinase inhibitor 1A (p21, Cip1)
- domestic cat(493943) cyclin-dependent kinase inhibitor 1A (p21, Cip1)
- naked mole-rat(101710552) cyclin-dependent kinase inhibitor 1A (p21, Cip1)
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-p21/WAF1/Cip1 Antibody, clone CP74, clone CP74, Upstate®, from mouse,
Species Reactivity
human
Application
immunohistochemistry
western blot
western blot
Anti-p21/WAF1/Cip1 Antibody, Upstate®, from mouse,
Species Reactivity
human, mouse
Application
immunoprecipitation (IP)
western blot
western blot