CDK4
cyclin-dependent kinase 4
Synonyms:
CMM3, PSK-J3
Species:
Human CDK4 (1019), Mouse Cdk4 (12567), Rat Cdk4 (94201), naked mole-rat Cdk4 (101702608), domestic guinea pig Cdk4 (100717960), cow CDK4 (510618), Domestic Rabbit CDK4 (100009039), Zebrafish cdk4 (777730), domestic cat CDK4 (101097903), dog CDK4 (481131) ...More
UniProtKB ID:
Gene ID:
- Human(1019) Summary: The protein encoded by this gene is a member of the Ser/Thr protein kinase family. This protein is highly similar to the gene products of S. cerevisiae cdc28 and S. pombe cdc2. It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. Multiple polyadenylation sites of this gene have been reported. [provided by RefSeq, Jul 2008]
- Mouse(12567) cyclin-dependent kinase 4
- Rat(94201) cyclin-dependent kinase 4
- naked mole-rat(101702608) cyclin-dependent kinase 4
- domestic guinea pig(100717960) cyclin-dependent kinase 4
- cow(510618) cyclin-dependent kinase 4
- Domestic Rabbit(100009039) cyclin-dependent kinase 4
- Zebrafish(777730) cyclin-dependent kinase 4
- domestic cat(101097903) cyclin-dependent kinase 4
- dog(481131) cyclin-dependent kinase 4
- sheep(100144756) cyclin-dependent kinase 4
- fruit fly(36854) Cyclin-dependent kinase 4
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Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Cdk4 Antibody, clone DCS-35, clone DCS-35, Chemicon®, from mouse,
Species Reactivity
human, mouse, pig, rat
Application
activity assay
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
immunofluorescence
immunohistochemistry
immunoprecipitation (IP)
western blot
Monoclonal Anti-Cdk4 antibody produced in mouse, clone DCS-31, ascites fluid,
Species Reactivity
human, mouse, rat
Application
immunocytochemistry
immunoprecipitation (IP)
microarray
western blot
immunoprecipitation (IP)
microarray
western blot