CCND2
cyclin D2
Synonyms:
KIAK0002
Species:
Human CCND2 (894), Mouse Ccnd2 (12444), Rat Ccnd2 (64033), domestic guinea pig Ccnd2 (100730596), naked mole-rat Ccnd2 (101721480), chicken CCND2 (374047), dog CCND2 (611782), cow CCND2 (615414), domestic cat CCND2 (101090950), sheep CCND2 (100147799)
UniProtKB ID:
Gene ID:
- Human(894) Summary: The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with and be involved in the phosphorylation of tumor suppressor protein Rb. Knockout studies of the homologous gene in mouse suggest the essential roles of this gene in ovarian granulosa and germ cell proliferation. High level expression of this gene was observed in ovarian and testicular tumors. [provided by RefSeq, Oct 2008]
- Mouse(12444) cyclin D2
- Rat(64033) cyclin D2
- domestic guinea pig(100730596) cyclin D2
- naked mole-rat(101721480) cyclin D2
- chicken(374047) cyclin D2
- dog(611782) cyclin D2
- cow(615414) cyclin D2
- domestic cat(101090950) cyclin D2
- sheep(100147799) cyclin D2
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