CCDC88A
coiled-coil domain containing 88A
Synonyms:
APE, GIRDIN, GIV, GRDN, HkRP1, KIAA1212
Species:
Human CCDC88A (55704), Mouse Ccdc88a (108686), Rat Ccdc88a (305605), cow CCDC88A (533248), sheep CCDC88A (101122010), domestic cat CCDC88A (101096803), dog CCDC88A (481375), Domestic Rabbit CCDC88A (100346692), naked mole-rat Ccdc88a (101708183), domestic guinea pig Ccdc88a (100714383) ...More
UniProtKB ID:
Gene ID:
- Human(55704) Summary: This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]
- Mouse(108686) coiled coil domain containing 88A
- Rat(305605) coiled coil domain containing 88A
- cow(533248) coiled-coil domain containing 88A
- sheep(101122010) coiled-coil domain containing 88A
- domestic cat(101096803) coiled-coil domain containing 88A
- dog(481375) coiled-coil domain containing 88A
- Domestic Rabbit(100346692) coiled-coil domain containing 88A
- naked mole-rat(101708183) coiled-coil domain containing 88A
- domestic guinea pig(100714383) coiled-coil domain containing 88A
- Horse(100052471) coiled-coil domain containing 88A
- chicken(421210) coiled-coil domain containing 88A
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