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Merck

CARD8

caspase recruitment domain family, member 8

Synonyms:
CARDINAL, DACAR, DAKAR, NDPP, NDPP1, TUCAN
Species:
Human CARD8 (22900), dog CARD8 (491519), domestic cat CARD8 (101093817), chicken CARD8 (416998)
UniProtKB ID:
Q9Y2G2, B5KVR6, B7Z496, B7Z4A2, E9PEM7, G3XAM9, Q6PGP8, Q96P82
Gene ID:
  • Human(22900) Summary: The protein encoded by this gene belongs to the caspase recruitment domain (CARD)-containing family of proteins, which are involved in pathways leading to activation of caspases or nuclear factor kappa-B (NFKB). This protein may be a component of the inflammasome, a protein complex that plays a role in the activation of proinflammatory caspases. It is thought that this protein acts as an adaptor molecule that negatively regulates NFKB activation, CASP1-dependent IL1B secretion, and apoptosis. Polymorphisms in this gene may be associated with a susceptibility to rheumatoid arthritis. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]
  • dog(491519) caspase recruitment domain family, member 8
  • domestic cat(101093817) caspase recruitment domain family, member 8
  • chicken(416998) caspase recruitment domain family, member 8

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