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Merck

CACNA1B

calcium channel, voltage-dependent, N type, alpha 1B subunit

Synonyms:
BIII, CACNL1A5, CACNN, Cav2.2
Species:
UniProtKB ID:
Gene ID:
  • Human(774) Summary: The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
  • Mouse(12287) calcium channel, voltage-dependent, N type, alpha 1B subunit
  • Rat(257648) calcium channel, voltage-dependent, N type, alpha 1B subunit
  • cow(282410) calcium channel, voltage-dependent, N type, alpha 1B subunit
  • chicken(374169) calcium channel, voltage-dependent, N type, alpha 1B subunit
  • dog(480660) calcium channel, voltage-dependent, N type, alpha 1B subunit
  • Domestic Rabbit(100008979) calcium channel, voltage-dependent, N type, alpha 1B subunit
  • naked mole-rat(101697609) calcium channel, voltage-dependent, N type, alpha 1B subunit
  • domestic guinea pig(100735203) calcium channel, voltage-dependent, N type, alpha 1B subunit
  • domestic cat(101087362) calcium channel, voltage-dependent, N type, alpha 1B subunit

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Small Molecule - Allosteric Modulator

Product Number
Description
Species
Levetiracetam, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Gabapentin, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Pregabalin, European Pharmacopoeia (EP) Reference Standard,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-Cav2.2 Antibody, Chemicon®, from rabbit,
Species Reactivity
rat
Application
immunocytochemistry
immunohistochemistry

immunoprecipitation (IP)

western blot

Small Molecule - Blocker

Product Number
Description
Species
Levetiracetam, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human