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Merck

CACNA1A

calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

Synonyms:
APCA, BI, CACNL1A4, CAV2.1, EA2, FHM, HPCA, MHP, MHP1, SCA6
Species:
Human CACNA1A (773), Mouse Cacna1a (12286), Rat Cacna1a (25398), sheep CACNA1A (101120920), domestic cat CACNA1A (101094827), Domestic Rabbit CACNA1A (100009265), cow CACNA1A (282648), dog CACNA1A (100686650), naked mole-rat Cacna1a (101725815), domestic guinea pig Cacna1a (100726277)
UniProtKB ID:
O00555, J3KP41, P78510, P78511, Q16290, Q92690, Q99790, Q99791
Gene ID:
  • Human(773) Summary: Voltage-dependent calcium channels mediate the entry of calcium ions into excitable cells, and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, and gene expression. Calcium channels are multisubunit complexes composed of alpha-1, beta, alpha-2/delta, and gamma subunits. The channel activity is directed by the pore-forming alpha-1 subunit, whereas, the others act as auxiliary subunits regulating this activity. The distinctive properties of the calcium channel types are related primarily to the expression of a variety of alpha-1 isoforms, alpha-1A, B, C, D, E, and S. This gene encodes the alpha-1A subunit, which is predominantly expressed in neuronal tissue. Mutations in this gene are associated with 2 neurologic disorders, familial hemiplegic migraine and episodic ataxia 2. This gene also exhibits polymorphic variation due to (CAG)n-repeats. Multiple transcript variants encoding different isoforms have been found for this gene. In one set of transcript variants, the (CAG)n-repeats occur in the 3' UTR, and are not associated with any disease. But in another set of variants, an insertion extends the coding region to include the (CAG)n-repeats which encode a polyglutamine tract. Expansion of the (CAG)n-repeats from the normal 4-16 to 21-28 in the coding region is associated with spinocerebellar ataxia 6. [provided by RefSeq, Mar 2010]
  • Mouse(12286) calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
  • Rat(25398) calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
  • sheep(101120920) calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
  • domestic cat(101094827) calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
  • Domestic Rabbit(100009265) calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
  • cow(282648) calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
  • dog(100686650) calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
  • naked mole-rat(101725815) calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
  • domestic guinea pig(100726277) calcium channel, voltage-dependent, P/Q type, alpha 1A subunit
  • dog(100126772) calcium channel, voltage-dependent, P/Q type, alpha 1A subunit

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Small Molecule - Allosteric Modulator

Product Number
Description
Species
PHR1049
Gabapentin, Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human
Y0001805
Pregabalin, European Pharmacopoeia (EP) Reference Standard,
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
AB5152
Anti-Calcium Channel Antibody, Voltage Gated α 1A, Chemicon®, from rabbit,
Species Reactivity
mouse, rat
Application
immunocytochemistry
immunoprecipitation (IP)
western blot