Skip to Content
Merck

C4A

complement component 4A (Rodgers blood group)

Synonyms:
C4, C4A2, C4A3, C4A4, C4A6, C4AD, C4S, CO4, CPAMD2, RG
Species:
Human C4A (720), Mouse C4a (625018), Rat C4a (24233), Horse C4A (100059239), dog C4A (481722), naked mole-rat C4a (101719002), domestic guinea pig C4a (100728345), Domestic Rabbit C4A (100356976), sheep C4A (101123672), cow C4A (280678)
UniProtKB ID:
P0C0L4, A6H8M8, A6NHJ5, A7E2V2, B0QZR6, B0V2C8, B2RUT6, B7ZVZ6
Gene ID:
  • Human(720) Summary: This gene encodes the acidic form of complement factor 4, part of the classical activation pathway. The protein is expressed as a single chain precursor which is proteolytically cleaved into a trimer of alpha, beta, and gamma chains prior to secretion. The trimer provides a surface for interaction between the antigen-antibody complex and other complement components. The alpha chain may be cleaved to release C4 anaphylatoxin, a mediator of local inflammation. Deficiency of this protein is associated with systemic lupus erythematosus and type I diabetes mellitus. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. Varying haplotypes of this gene cluster exist, such that individuals may have 1, 2, or 3 copies of this gene. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]
  • Mouse(625018) complement component 4A (Rodgers blood group)
  • Rat(24233) complement component 4A (Rodgers blood group)
  • Horse(100059239) complement component 4A (Rodgers blood group)
  • dog(481722) complement component 4A (Rodgers blood group)
  • naked mole-rat(101719002) complement component 4A (Rodgers blood group)
  • domestic guinea pig(100728345) complement component 4A (Rodgers blood group)
  • Domestic Rabbit(100356976) complement component 4A (Rodgers blood group)
  • sheep(101123672) complement component 4A (Rodgers blood group)
  • cow(280678) complement component 4A

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.