BCCIP
BRCA2 and CDKN1A interacting protein
Synonyms:
TOK-1, TOK1
Species:
Human BCCIP (56647), Mouse Bccip (66165), Rat Bccip (361666), dog BCCIP (477864), Zebrafish bccip (541348), chicken BCCIP (426225), naked mole-rat Bccip (101721059), domestic cat BCCIP (101100756), cow BCCIP (512466), sheep BCCIP (101116189)
UniProtKB ID:
Gene ID:
- Human(56647) Summary: This gene product was isolated on the basis of its interaction with BRCA2 and p21 proteins. It is an evolutionarily conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions of calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via p21. This protein has also been implicated in the regulation of BRCA2 and RAD51 nuclear focus formation, double-strand break-induced homologous recombination, and cell cycle progression. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
- Mouse(66165) BRCA2 and CDKN1A interacting protein
- Rat(361666) BRCA2 and CDKN1A interacting protein
- dog(477864) BRCA2 and CDKN1A interacting protein
- Zebrafish(541348) BRCA2 and CDKN1A interacting protein
- chicken(426225) BRCA2 and CDKN1A interacting protein
- naked mole-rat(101721059) BRCA2 and CDKN1A interacting protein
- domestic cat(101100756) BRCA2 and CDKN1A interacting protein
- cow(512466) BRCA2 and CDKN1A interacting protein
- sheep(101116189) BRCA2 and CDKN1A interacting protein
- domestic guinea pig(100733090) BRCA2 and CDKN1A interacting protein
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