AREG
amphiregulin
Synonyms:
AR, CRDGF, SDGF
Species:
UniProtKB ID:
Gene ID:
- Human(374) Summary: The protein encoded by this gene is a member of the epidermal growth factor family. It is an autocrine growth factor as well as a mitogen for astrocytes, Schwann cells, and fibroblasts. It is related to epidermal growth factor (EGF) and transforming growth factor alpha (TGF-alpha). This protein interacts with the EGF/TGF-alpha receptor to promote the growth of normal epithelial cells and inhibits the growth of certain aggressive carcinoma cell lines. This encoded protein is associated with a psoriasis-like skin phenotype. [provided by RefSeq, Jul 2008]
- Mouse(11839) amphiregulin
- Rat(29183) amphiregulin
- sheep(443427) amphiregulin
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