APOE
apolipoprotein E
Synonyms:
AD2, LDLCQ5, LPG
Species:
Human APOE (348), Mouse Apoe (11816), Rat Apoe (25728), naked mole-rat Apoe (101717206), domestic guinea pig Apoe (100731633), cow APOE (281004), Domestic Rabbit APOE (100009337), dog APOE (476438), domestic cat APOE (101086769)
UniProtKB ID:
Gene ID:
- Human(348) Summary: Chylomicron remnants and very low density lipoprotein (VLDL) remnants are rapidly removed from the circulation by receptor-mediated endocytosis in the liver. Apolipoprotein E, a main apoprotein of the chylomicron, binds to a specific receptor on liver cells and peripheral cells. ApoE is essential for the normal catabolism of triglyceride-rich lipoprotein constituents. The APOE gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. [provided by RefSeq, Jul 2008]
- Mouse(11816) apolipoprotein E
- Rat(25728) apolipoprotein E
- naked mole-rat(101717206) apolipoprotein E
- domestic guinea pig(100731633) apolipoprotein E
- cow(281004) apolipoprotein E
- Domestic Rabbit(100009337) apolipoprotein E
- dog(476438) apolipoprotein E
- domestic cat(101086769) apolipoprotein E
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