AKT1
v-akt murine thymoma viral oncogene homolog 1
Synonyms:
AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA
Species:
Human AKT1 (207), Mouse Akt1 (11651), Rat Akt1 (24185), cow AKT1 (280991), fruit fly Akt1 (41957), chicken AKT1 (395928), Zebrafish akt1 (101910198), Goat AKT1 (100860904), sheep AKT1 (100294652), dog AKT1 (490878) ...More
UniProtKB ID:
Gene ID:
- Human(207) Summary: The serine-threonine protein kinase encoded by the AKT1 gene is catalytically inactive in serum-starved primary and immortalized fibroblasts. AKT1 and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is abrogated by mutations in the pleckstrin homology domain of AKT1. It was shown that the activation occurs through phosphatidylinositol 3-kinase. In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can suppress apoptosis in a transcription-independent manner by activating the serine/threonine kinase AKT1, which then phosphorylates and inactivates components of the apoptotic machinery. Mutations in this gene have been associated with the Proteus syndrome. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2011]
- Mouse(11651) thymoma viral proto-oncogene 1
- Rat(24185) v-akt murine thymoma viral oncogene homolog 1
- cow(280991) v-akt murine thymoma viral oncogene homolog 1
- fruit fly(41957) CG4006 gene product from transcript CG4006-RA
- chicken(395928) v-akt murine thymoma viral oncogene homolog 1
- Zebrafish(101910198) v-akt murine thymoma viral oncogene homolog 1
- Goat(100860904) v-akt murine thymoma viral oncogene homolog 1
- sheep(100294652) v-akt murine thymoma viral oncogene homolog 1
- dog(490878) v-akt murine thymoma viral oncogene homolog 1
- domestic guinea pig(100714724) v-akt murine thymoma viral oncogene homolog 1
- sheep(101104184) v-akt murine thymoma viral oncogene homolog 1
- domestic cat(101087931) v-akt murine thymoma viral oncogene homolog 1
- naked mole-rat(101700695) v-akt murine thymoma viral oncogene homolog 1
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ELISA
Product Number
Description
Species
Phospho-Akt (pSer473) / pan-Akt ELISA Kit, for detection of human, mouse or rat phospho-akt (pSer473) and pan-akt in cell and tissue lysates,
Species
human
Phospho-Akt (pSer473) ELISA Kit, for detection of human, mouse or rat phospho-akt (pSer473) in cell and tissue lysates,
Species
human
Antibodies
Product Number
Description
Species Reactivity
Application
Anti-Akt/PKB Antibody, PH Domain, clone SKB1, Alexa Fluor™ 488, clone SKB1, Upstate®, from mouse,
Species Reactivity
human, mouse, rat
Application
flow cytometry
immunocytochemistry
immunofluorescence
western blot
immunocytochemistry
immunofluorescence
western blot
Anti-phospho-AKT (Thr34) Antibody, Upstate®, from rabbit,
Species Reactivity
human
Application
western blot
Anti-Akt1/PKBα Antibody, clone AW24 | 04-796, clone AW24, from rabbit,
Species Reactivity
human, mouse, rat
Application
immunoprecipitation (IP)
western blot
western blot
Anti-Akt1/PKBα Antibody, Upstate®, from rabbit,
Species Reactivity
human, mouse, rat
Application
immunoprecipitation (IP)
western blot
western blot
Anti-phospho-Akt1/PKBα (Ser473) Antibody, clone SK703, rabbit monoclonal, culture supernatant, clone SK703, Upstate®,
Species Reactivity
human, mouse
Application
western blot
Small Molecule - Inhibitor
Proteins
Product Number
Description
Species
Akt1/PKBα Protein, active, 15 µg, Active, recombinant full-length human Akt1, containing N-terminal His6 tag, for use in IP-Kinase Assays & Kinase Assays.,
Species
human