ADRA2B
adrenoceptor alpha 2B
Synonyms:
ADRA2L1, ADRA2RL1, ADRARL1, ALPHA2BAR, alpha-2BAR
Species:
Human ADRA2B (151), Mouse Adra2b (11552), Rat Adra2b (24174), cow ADRA2B (516422), naked mole-rat Adra2b (101701692), chicken ADRA2B (427631), domestic cat ADRA2B (101090432), domestic guinea pig Adra2b (100135476), Zebrafish adra2b (266751), domestic guinea pig Adra2b (100727868) ...More
UniProtKB ID:
Gene ID:
- Human(151) Summary: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. This intronless gene encodes the alpha2B subtype, which was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. [provided by RefSeq, Aug 2011]
- Mouse(11552) adrenergic receptor, alpha 2b
- Rat(24174) adrenoceptor alpha 2B
- cow(516422) adrenergic, alpha-2B-, receptor
- naked mole-rat(101701692) adrenoceptor alpha 2B
- chicken(427631) adrenergic, alpha-2B-, receptor
- domestic cat(101090432) adrenoceptor alpha 2B
- domestic guinea pig(100135476) adrenergic receptor, alpha 2b
- Zebrafish(266751) adrenergic, alpha-2B-, receptor
- domestic guinea pig(100727868) adrenoceptor alpha 2B
- dog(611658) adrenergic, alpha-2B-, receptor
- Horse(100051684) adrenoceptor alpha 2B
- sheep(100170318) adrenoceptor alpha 2B
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Small Molecule - Agonist
Product Number
Description
Species
Small Molecule - Antagonist
Product Number
Description
Species
Mirtazapine for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human