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Merck

ADRA2A

adrenoceptor alpha 2A

Synonyms:
ADRA2, ADRA2R, ADRAR, ALPHA2AAR, ZNF32
Species:
UniProtKB ID:
Gene ID:
  • Human(150) Summary: Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Studies in mouse revealed that both the alpha2A and alpha2C subtypes were required for normal presynaptic control of transmitter release from sympathetic nerves in the heart and from central noradrenergic neurons; the alpha2A subtype inhibited transmitter release at high stimulation frequencies, whereas the alpha2C subtype modulated neurotransmission at lower levels of nerve activity. This gene encodes alpha2A subtype and it contains no introns in either its coding or untranslated sequences. [provided by RefSeq, Jul 2008]
  • Mouse(11551) adrenergic receptor, alpha 2a
  • Rat(25083) adrenoceptor alpha 2A
  • domestic guinea pig(100135475) adrenergic receptor, alpha 2a
  • chicken(428980) adrenergic, alpha-2A-, receptor
  • sheep(100170317) adrenoceptor alpha 2A
  • Domestic Rabbit(100009424) adrenoceptor alpha 2A
  • Zebrafish(266750) adrenergic, alpha-2A-, receptor
  • dog(486888) adrenoceptor alpha 2A
  • domestic cat(664736) adrenoceptor alpha 2A
  • sheep(101117291) adrenoceptor alpha 2A
  • naked mole-rat(101723298) adrenoceptor alpha 2A
  • cow(282135) adrenergic, alpha-2A-, receptor

Custom & Knockdown Gene Products

Small Molecule - Agonist

Product Number
Description
Species
Methyldopa, British Pharmacopoeia (BP) Reference Standard,
Species
human
Methyldopa, United States Pharmacopeia (USP) Reference Standard,
Species
human
Guanfacine hydrochloride, United States Pharmacopeia (USP) Reference Standard,
Species
human
Methyldopa for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
Methyldopa, European Pharmacopoeia (EP) Reference Standard,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
Mirtazapine, British Pharmacopoeia (BP) Reference Standard,
Species
human
Mirtazapine, United States Pharmacopeia (USP) Reference Standard,
Species
human
Mirtazapine, European Pharmacopoeia (EP) Reference Standard,
Species
human
Mirtazapine for system suitability, European Pharmacopoeia (EP) Reference Standard,
Species
human
Phentolamine mesylate, United States Pharmacopeia (USP) Reference Standard,
Species
human