ACTL7A
actin-like 7A
Synonyms:
Species:
Human ACTL7A (10881), Mouse Actl7a (11470), Rat Actl7a (298017), dog ACTL7A (474795), sheep ACTL7A (101115937), naked mole-rat Actl7a (101724648), domestic guinea pig Actl7a (100728303), cow ACTL7A (540296), domestic cat ACTL7A (101087109)
UniProtKB ID:
Gene ID:
- Human(10881) Summary: The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene (ACTL7A), and related gene, ACTL7B, are intronless, and are located approximately 4 kb apart in a head-to-head orientation within the familial dysautonomia candidate region on 9q31. Based on mutational analysis of the ACTL7A gene in patients with this disorder, it was concluded that it is unlikely to be involved in the pathogenesis of dysautonomia. The ACTL7A gene is expressed in a wide variety of adult tissues, however, its exact function is not known. [provided by RefSeq, Jul 2008]
- Mouse(11470) actin-like 7a
- Rat(298017) actin-like 7a
- dog(474795) actin-like 7A
- sheep(101115937) actin-like 7A
- naked mole-rat(101724648) actin-like 7A
- domestic guinea pig(100728303) actin-like 7A
- cow(540296) actin-like 7A
- domestic cat(101087109) actin-like 7A
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