ACLY
ATP citrate lyase
Synonyms:
ACL, ATPCL, CLATP
Species:
Human ACLY (47), Mouse Acly (104112), Rat Acly (24159), chicken ACLY (395373), naked mole-rat Acly (101700349), domestic guinea pig Acly (100714933), dog ACLY (607852), Horse ACLY (100053195), domestic cat ACLY (100422779), cow ACLY (511135)
UniProtKB ID:
Gene ID:
- Human(47) Summary: ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
- Mouse(104112) ATP citrate lyase
- Rat(24159) ATP citrate lyase
- chicken(395373) ATP citrate lyase
- naked mole-rat(101700349) ATP citrate lyase
- domestic guinea pig(100714933) ATP citrate lyase
- dog(607852) ATP citrate lyase
- Horse(100053195) ATP citrate lyase
- domestic cat(100422779) ATP citrate lyase
- cow(511135) ATP citrate lyase
- sheep(654404) ATP citrate lyase
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