ABL1
c-abl oncogene 1, non-receptor tyrosine kinase
Synonyms:
ABL, JTK7, bcr/abl, c-ABL, p150, v-abl
Species:
Human ABL1 (25), Mouse Abl1 (11350), Rat Abl1 (311860), chicken ABL1 (417181), domestic cat ABL1 (101087622), Zebrafish abl1 (100000720), cow ABL1 (540876), naked mole-rat Abl1 (101724428), Horse ABL1 (100069715), domestic guinea pig Abl1 (100720976) ...More
UniProtKB ID:
Gene ID:
- Human(25) Summary: The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. [provided by RefSeq, Jul 2008]
- Mouse(11350) c-abl oncogene 1, non-receptor tyrosine kinase
- Rat(311860) c-abl oncogene 1, non-receptor tyrosine kinase
- chicken(417181) c-abl oncogene 1, non-receptor tyrosine kinase
- domestic cat(101087622) c-abl oncogene 1, non-receptor tyrosine kinase
- Zebrafish(100000720) c-abl oncogene 1, receptor tyrosine kinase
- cow(540876) c-abl oncogene 1, non-receptor tyrosine kinase
- naked mole-rat(101724428) c-abl oncogene 1, non-receptor tyrosine kinase
- Horse(100069715) c-abl oncogene 1, non-receptor tyrosine kinase
- domestic guinea pig(100720976) c-abl oncogene 1, non-receptor tyrosine kinase
- dog(491292) c-abl oncogene 1, non-receptor tyrosine kinase
- sheep(101122941) c-abl oncogene 1, non-receptor tyrosine kinase
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