ABCC8
ATP-binding cassette, sub-family C (CFTR/MRP), member 8
Synonyms:
ABC36, HHF1, HI, HRINS, MRP8, PHHI, SUR, SUR1, SUR1delta2, TNDM2
Species:
Human ABCC8 (6833), Mouse Abcc8 (20927), Rat Abcc8 (25559), domestic cat ABCC8 (101096101), sheep ABCC8 (101120522), naked mole-rat Abcc8 (101705546), domestic guinea pig Abcc8 (100722700), Zebrafish abcc8 (553281), chicken ABCC8 (423072), dog ABCC8 (485402) ...More
UniProtKB ID:
Gene ID:
- Human(6833) Summary: The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein functions as a modulator of ATP-sensitive potassium channels and insulin release. Mutations and deficiencies in this protein have been observed in patients with hyperinsulinemic hypoglycemia of infancy, an autosomal recessive disorder of unregulated and high insulin secretion. Mutations have also been associated with non-insulin-dependent diabetes mellitus type II, an autosomal dominant disease of defective insulin secretion. Alternative splicing of this gene has been observed; however, the transcript variants have not been fully described. [provided by RefSeq, Jul 2008]
- Mouse(20927) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
- Rat(25559) ATP-binding cassette, subfamily C (CFTR/MRP), member 8
- domestic cat(101096101) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
- sheep(101120522) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
- naked mole-rat(101705546) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
- domestic guinea pig(100722700) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
- Zebrafish(553281) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
- chicken(423072) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
- dog(485402) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
- Horse(100071788) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
- cow(538996) ATP-binding cassette, sub-family C (CFTR/MRP), member 8
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Small Molecule - Blocker
Product Number
Description
Species
Glyburide (Glibenclamide), Pharmaceutical Secondary Standard; Certified Reference Material,
Species
human